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A new research suggests that if you take the erectile dysfunction drug sildenafil, it can cause an unsafe drop in blood pressure.

A new study suggests that if you take the erectile dysfunction drug sildenafil, it can cause an unsafe drop in blood pressure.

The researchers reviewed more than 1,300 cases of erectile dysfunction among patients taking a class of drugs called phosphodiesterase-5 inhibitors. They found that patients taking these drugs had a significantly higher risk of being diagnosed with the dangerous dangerous type of hypertension, also known as the erectile dysfunction.

“Sildenafil, or Viagra, is a widely-used drug for the treatment of erectile dysfunction, but its effects on blood pressure can be dangerous,” said Dr. Steven Nissen, a urologist at New York University Langone Medical Center in New York City.

The study, which was published in theNew England Journal of Medicinein early 2022, was conducted in collaboration with the National Institute of Health, and involved more than 600 men with erectile dysfunction who were prescribed sildenafil. They were randomly assigned to receive a placebo for 24 weeks, or to receive sildenafil in the form of a pill every other day for 10 weeks.

The men in the placebo group took their daily sildenafil pill for the first time and reported a significantly lower blood pressure. The men taking sildenafil reported a significantly lower risk of hypertension than those who did not take their daily pill.

Dr. Nissen said the risk of hypertension is relatively small. “This is the first large, controlled trial of this class of medication to directly compare the safety and effectiveness of sildenafil with that of other classes of medications for erectile dysfunction,” he said.

The men in the study who took the erectile dysfunction drug sildenafil had an average of one-third fewer blood pressure readings than those who did not take their daily pill. They also had a significantly lower risk of heart attacks, strokes, hospitalizations, and death from any cause.

“This is the first large-scale, placebo-controlled trial that compares sildenafil with other classes of medications for erectile dysfunction that are safe, effective, and associated with a statistically significant lower risk of hypertension and other cardiovascular events,” Dr. Nissen said.

He noted that patients taking the erectile dysfunction drug sildenafil may be at higher risk of developing heart disease.

“The association between erectile dysfunction and hypertension is probably causal, and the association is probably more likely when erectile dysfunction is a result of underlying cardiovascular conditions rather than secondary causes,” he said.

Nissen noted that although some erectile dysfunction drugs have a relatively safe effect on blood pressure, the study did not find a significant difference in side effects between the groups.

“This is the first large-scale, controlled trial that compares the safety and effectiveness of sildenafil with that of other classes of medications for erectile dysfunction, such as nitrates and alpha-blockers,” he added.

Sildenafil and tadalafil are the first drugs approved by the Food and Drug Administration to treat erectile dysfunction. However, they are not approved by the FDA for this use.

A recent, published in theJournal of Sexual Medicine, found that people taking tadalafil had a significantly higher risk of developing heart attack, stroke, and death from any cause. The researchers also noted that people taking sildenafil had a higher risk of developing heart failure, hypertension, and congestive heart failure.

“The association between sildenafil and heart failure and cardiovascular events in the general population remains controversial, and there is some evidence that a higher incidence of these events could be related to the use of the drug,” Dr.

“This study provides a potential explanation for the relatively modest association between the use of sildenafil and heart failure and congestive heart failure in this population,” he added.

In the study, the researchers also compared the risk of hypertension to the risk of heart disease and found that patients on sildenafil had a significantly higher risk of heart attacks. The risk of these events was similar to that of patients on nitrates.

Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Viagra use include:

  • Headache
  • Heartburn
  • Congestion
  • Nasal bleeding (bloody nose)
  • Nausea
  • Diarrhea
  • Muscle aches or pains
  • Flushing
  • Facial pain or tenderness
  • Vision changes
  • Light sensitivity

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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In the US, 1 in 10 asthma attacks are preventable, effectively. However, there are strategies that can help reduce the risk of developing this side effect, such as using anti-inflammatory medications, using regular exercise, and using physical therapy. Some asthma medications, like albuterol, can also reduce the heart’s ability to pump blood through the lungs, making it easier to breathe.

In addition, there are several lifestyle changes that can help reduce the risk of developing asthma attack symptoms. For example, losing weight can help reduce the risk of developing asthma attacks, while using exercise can help reduce the risk of developing asthma.

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Viagra can cause an increase in the amount of urine produced. This can lead to symptoms like:

  • Increase in urination
  • Painful erections

If you experience any side effects that are severe, seek medical attention immediately.

As with all prescription medications, inform your doctor if you are currently receiving other medication, enzyme, or supplements. Many medications, like nitrates, can cause serious cardiovascular effects, so inform your health care provider of all medications you are taking. As with all prescription medications, inform your doctor if you are currently taking any of the following:

  • Alpha-blockers (like doxazosin, tamsulosin)
  • Anticoagulants (like warfarin)
  • Antiepileptic drugs (antiviral drugs)
  • Blood pressure medications (like diuretics)
  • Calcium channel blockers (like phentolamine, verapamil)
  • Corticosteroids (like prednisone)
  • Cyclosporine
  • Diuretics (like feldefense)
  • Furosemide

Viagra can interact with other medications, so you should inform your health care provider about any other medications you are taking.

Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Product variants
NameProductPrice
Sildenafil 25mg£16.80£28.40
Sildenafil 50mg£21.50£23.20
Sildenafil 100mg£27.20£27.50

FAQs

How long does it take for Sildenafil to work?Sildenafil does not affect sexual desire or ability for up to 36 hours.

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